| 胡椒乙胺 | 1,3-Benzodioxole-5-ethanamine | 1484-85-1 |
化合物简介
3,4-Methylenedioxyphenethylamine (MDPEA), also known as homopiperonylamine, is a substituted phenethylamine formed by adding a methylenedioxy group to phenethylamine. It is structurally similar to MDA, but without the methyl group at the alpha position.
According to Alexander Shulgin in his book PiHKAL, MDPEA appears to be biologically inactive. This is likely because of extensive first-pass metabolism by the enzyme monoamine oxidase. However, if MDPEA were either used in high enough of doses (e.g., 1-2 grams), or in combination with a monoamine oxidase inhibitor (MAOI), it is probable that it would become sufficiently active, though it would likely have a relatively short duration of action. This idea is similar in concept to the use of selective MAOA inhibitors and selective MAOB inhibitors in augmentation of dimethyltryptamine (DMT) and phenethylamine (PEA), respectively.
According to Alexander Shulgin in his book PiHKAL, MDPEA appears to be biologically inactive. This is likely because of extensive first-pass metabolism by the enzyme monoamine oxidase. However, if MDPEA were either used in high enough of doses (e.g., 1-2 grams), or in combination with a monoamine oxidase inhibitor (MAOI), it is probable that it would become sufficiently active, though it would likely have a relatively short duration of action. This idea is similar in concept to the use of selective MAOA inhibitors and selective MAOB inhibitors in augmentation of dimethyltryptamine (DMT) and phenethylamine (PEA), respectively.
基本信息
- 中文名称：
- 胡椒乙胺
- 中文别名：
- 3,4-亚甲二氧基苯乙胺;
2-(3,4-亚甲二氧苯基)乙胺;
3,4-亚甲二氧苯乙胺;
- 英文名称：
- 2-(1,3-benzodioxol-5-yl)ethanamine
- 英文别名：
- 3,4-Methylenedioxyphenethylamine;
EINECS 216-060-8;
1,3-Benzodioxole-5-ethanamine;
3,4-methylenedioxyphenylethylamine;
Methylenedioxyphenylethylamine;
查看更多英文别名
- CAS号：
- 1484-85-1
- 分子式：
- C9H11NO2
- 分子量：
- 165.18900
- 精确质量：
- 165.07900
- PSA：
- 44.48000
- LogP：
- 1.61680
物化性质
- 外观与性状：
- 无色液体
- 密度：
- 0.689 g/mL at 25 °C(lit.)
- 熔点：
- −131.5-−131 °C(lit.)
- 沸点：
- 64-65 °C(lit.)
- 闪点：
- −15 °F
- 折射率：
- n20/D 1.396(lit.)
- 蒸汽压：
- 0.000618mmHg at 25°C
安全信息
- 包装等级：II
- 危险类别：3
- 海关编码：2935009090
- 危险品运输编码：UN 3295 3/PG 2
- WGK Germany：3
- 危险类别码：R11; R43; R51/53
- 安全说明：S36/37; S61
- 危险品标志：F; Xi; N
生产方法及用途
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生产方法
由胡椒乙腈或胡椒乙叉亚胺经催化加氢制得。将胡椒乙太亚胺、乙醇、镍触媒如入高压釜。用氮置换釜内空气后通入氨气,再通氢。控制压力3-4MPa、温度95-100℃,氢化反应进行至不再吸氢时算起,继续保温、保持氢压30min。冷却至30℃,降压静置,利用釜内余压出料过滤,除去镍触媒(浸入乙醇套用)。滤液先在常压蒸馏回收氨乙醇溶液,再进行减压蒸馏,收集110-140℃(1.33kPa)馏分,得胡椒乙胺。收率80%。采用胡椒乙腈生产时,工艺过程相仿,温度为80-85℃,压力为1MPa左右。得到含量为92-94%的胡椒乙胺。原料消耗定额:胡椒乙腈1050kg/t、兰尼镍23.4kg/t、氢70kg/t、乙醇(99%)982kg/t。
用途
该品是医药黄连素和多马胺的中间体。
