三光气与伯胺反应生成脲示例（Tetrahedron, 2002, 639-652）
To a stirred solution of 3-chloro-4-nitro-phenylamine (1.72 g,10 mmoL)and diisopropyl ethylamine (2.1 g, 20 mmol) in 100 mL of dry DCM was addeda solution of triphosgene (0.99 g, 3.3 mmol) in 10 mL of DCM. The resulting mixturewas stirred at 0 oC for 3 hours and then treated with aniline (930mg, 10 mmol). The reaction mixture was allowed to warm to room temperatureovernight. After removal of the solvent, the residue partitioned between ethylacetate and saturated bicarbonate solution. The organic layer was separated, washedwith brine, dried over anhydrous Na2SO4 and filtered. Thefiltrate was concentrated to the residue, which was purified by columnchromatography on silica to afford 1.9 g of the 1-(3-chloro-4-nitro-phenyl)-3- phenyl-urea(65 %).
异氰酸酯与胺反应生成脲示例（J. Med. Chem. 2005, 1697-1700）
To a solution of 3-chloro-4-nitro-phenylamine(1.72 g, 10 mmoL) and triethylamine (3 mL, 20 mmol) in 100 mL of THF was addedisocyanato-benzene (1.19 g, 10 mmol) in 10 mL of THF at 0 oCdropwise. After the addition was completed, the resulting mixture was allowedto raise room temperature and stirred overnight before being poured into water(150 mL). The mixture was extracted with DCM (3 x 100 mL). The combined organicphases were washed with brine, dried over anhydrous Na2SO4and filtered. The filtrate was concentrated to give the crude product, whichwas purified by column to afford 2.4 g of 1-(3-chloro-4-nitro-phenyl)-3- phenyl-urea(80 %)
三光气与仲胺反应氯甲酰胺 （ J. Org. Chem. 2004, 3787-3793）
To a solution of 2-allyl-piperidine (0.63 g, 5 mmol) and pyridine (0.52g, 6.6 mmol) in 50 mL of dichloromethane was added a solution of triphosgene(0.66 g, 2.2 mmol) in 10 mL of dichloromethane at 0 oC dropwise over40 min. The resulting mixture was then warmed to room temperature and stirredovernight. The reaction mixture was added 50 mL of 1 N of aqueous HCl solutiondropwise. After separation, the aqueous phase was extracted with DCM (3 x 50mL). The combined organic phases were washed with a saturatedNaHCO3solution and brine ( 3 x 50 mL ), then dried over MgSO4. After removal of the solvent, thecrude product was taken into Et2O andthe solids were filtered. The filtrate was concentrated to 860 mg of carbamoylchloride as yellow oil (92 %).
A solution of 2-allyl-piperidine-1-carbonylchloride (1.87 g, 10 mmol), triethylamine (5 mL), and 4-chloro-3-fluoro-phenylamine(1.7 g, 12 mmol) in 100 mL of anhydrous dioxane was stirred at room temperatureunder nitrogen for 26 h and then concentrated to dry under vacuum. The residuewas dissolved in 100 mL of dichloromethane, and washed with 0.5 N of aqueousHCl solution and brine, After dried over anhydrous Na2SO4and filtered, the filtrate was concentrated to the crude product, which was purifiedby flash column chromatography to afford 2-Allyl-piperidine-1-carboxylic acid(4-chloro-3-fluoro-phenyl)-amide (2.3g, 77 %)