由酮（如丙酮）和2-氨基-2-甲基-1-丙醇或1,2-二氨基丙烷在氯仿和氢氧化钠存在下反应制备取代吗啡啉酮或哌啶酮的反应。

反应机理

反应实例

参考文献

1. Bargellini, G. Gazz. Chim. Ital. 1906, 36, 329.

2. Lai, J. T. J. Org. Chem. 1980, 45, 754.

3. Lai, J. T. Synthesis 1981, 754.

4. Lai, J. T. Synthesis 1984, 122.

5. Lai, J. T. Synthesis 1984, 124.

6. Rychnovsky, S. D.; Beauchamp, T.; Vaidyanathan, R.; Kwan, T. J. Org. Chem. 1998,

63, 6363.

7. Cvetovich, R. J.; Chung, J. Y. L.; Kress, M. H.; Amato, J. S.; Zhou, G.; Matty, L.;

Tsay, F. R.; Li, Z. Abstracts of Papers, 226th ACS National Meeting, New York, NY,

United States, September 711, 2003 (2003), ORGN-078.

编译自：Name Reactions （A Collection of Detailed Reaction Mechanisms）, Jie Jack Li, Bargellini reaction，page 24-25.