1,2,3-三氮唑
288-36-8
纯度99%
化合物简介
1,2,3-Triazole is one of a pair of isomeric chemical compounds with molecular formula C2H3N3, called triazoles, which have a five-membered ring of two carbon atoms and three nitrogen atoms. 1,2,3-Triazole is a basic aromatic heterocycle.
Substituted 1,2,3-triazoles can be produced using the azide alkyne Huisgen cycloaddition in which an azide and an alkyne undergo a 1,3-dipolar cycloaddition reaction.
It is a surprisingly stable structure compared to other organic compounds with three adjacent nitrogen atoms. However, flash vacuum pyrolysis at 500 °C leads to loss of molecular nitrogen (N2) to produce aziridine. Certain triazoles are relatively easy to cleave due to so-called ring-chain tautomerism. One manifestation is found in the Dimroth rearrangement.
1,2,3-Triazole finds use in research as a building block for more complex chemical compounds, including pharmaceutical drugs such as tazobactam.
Substituted 1,2,3-triazoles can be produced using the azide alkyne Huisgen cycloaddition in which an azide and an alkyne undergo a 1,3-dipolar cycloaddition reaction.
It is a surprisingly stable structure compared to other organic compounds with three adjacent nitrogen atoms. However, flash vacuum pyrolysis at 500 °C leads to loss of molecular nitrogen (N2) to produce aziridine. Certain triazoles are relatively easy to cleave due to so-called ring-chain tautomerism. One manifestation is found in the Dimroth rearrangement.
1,2,3-Triazole finds use in research as a building block for more complex chemical compounds, including pharmaceutical drugs such as tazobactam.
基本信息
- 中文名称：
- 1H-1,2,3-三氮唑
- 中文别名：
- 1,2,3-三氮唑;
1H-1,2,3-三唑;
三氮唑;
- 英文名称：
- 1H-1,2,3-triazole
- 英文别名：
- V-triazole;
Osotriazole;
RIBAVIRIN USP24;
vic-triazole;
1-H-triazole;
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- CAS号：
- 288-36-8
- 分子式：
- C2H3N3
- 分子量：
- 69.06530
- 精确质量：
- 69.03270
- PSA：
- 41.57000
物化性质
- 外观与性状：
- 无色液体
- 密度：
- 1.192 g/mL at 25 °C(lit.)
- 熔点：
- 23-25 °C(lit.)
- 沸点：
- 203 °C752 mm Hg(lit.)
- 闪点：
- 225 °F
- 折射率：
- n20/D 1.498(lit.)
- 水溶解性：
- soluble
- 储存条件：
- Store in a cool, dry place. Store in a tightly closed container.
安全信息
- 海关编码：2933990090
- WGK Germany：3
- 危险类别码：R36/37/38
- 安全说明：S37/39-S26-S36/37
- 危险品标志：Xi
生产方法及用途
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用途
用作药物三唑巴坦中间体
