Fig. 5 | implementation and topology of the synthesis platform. a, Physical instance of the Chemputer used for the synthesis of NHS-diazirine. The discrete modules are highlighted in different colours and labelled. b, Representation of the same instance in graph format; the modules are highlighted according to the colour code used in a.
本工作表明,模块化方法可以统一不同类型有机反应的自动合成。目前工作的重点是扩展我们的模块库,以添加支持低温(−78°C),固体添加,光化学和电化学的反应。通过继续扩大化学计算的方法,硬件和软件结合将打造一个普遍的、开放的标准合成平台,将增加反应的协作和重现性,加快创新。Moreover, such a platform could not only facilitate autonomous discovery workflows that have access to a diverse set of small molecules but also allow us to version the synthesis of new and literature molecules.
S. Hessam M. Mehr, Matthew Craven, Artem I. Leonov, Graham Keenan, Leroy Cronin. A universal system for digitization and automatic execution of the chemical synthesis literature, Science 2020, 370, 101-108
DOI: 10.1126/science.abc2986
https://science.sciencemag.org/content/370/6512/101