纯度95%，200 mg
实单询价
化合物简介
OSU-03012 (AR-12) is a celecoxib derivative with anticancer and anti-microbial activity. Unlike celecoxib, OSU-03012 does not inhibit COX, but inhibits several other important enzymes instead which may be useful in the treatment of some forms of cancer, while also having antifungal activity via disruption of phosphoinositide-dependent kinase-1 activity. When combined with PDE5 inhibitors such as sildenafil or tadalafil, OSU-03012 was found to show enhanced anti-tumour, antibiotic and antiviral activity against a wide variety of organisms, with this activity thought to be mediated via inhibition of the chaperone protein BiP.
基本信息
- 中文名称：
- 2-氨基-N-[4-[5-(2-菲基)-3-(三氟甲基)-1H-吡唑-1-基]苯基]乙酰胺
- 中文别名：
- 达努塞替
- 英文名称：
- 2-amino-N-[4-[5-phenanthren-2-yl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]acetamide
- 英文别名：
- PDK1 inhibitor AR-12;
2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide;
- CAS号：
- 742112-33-0
- 分子式：
- C26H19F3N4O
- 分子量：
- 460.45000
- 精确质量：
- 460.15100
- PSA：
- 72.94000
- LogP：
- 6.53500
物化性质
- 密度：
- 1.369g/cm3
- 沸点：
- 683.017ºC at 760 mmHg
- 闪点：
- 366.876ºC
- 折射率：
- 1.649
