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1-甲基-1H-1,2,3-苯并噻唑-5-基)甲胺_CAS:499770-77-32017-07-12
产品属性

CAS号:499770-77-3

重量(克):50G

价格(元):询价

时间:2017-07-12 16:23:09

交易状态:等待报价

产品信息

CAS# 499770-77-3

1-甲基-1H-1,2,3-苯并噻唑-5-基)甲胺

50G

化合物简介

1,5-disubstituted benzotriazole derivative used as a building block in the preparation of hexahydropyrazinotriazinedione compounds as CYP3A4 inhibitors useful as reverse turn mimetics and in the treatment of cancer.

基本信息

中文名称:
(1-甲基-1H-1,2,3-苯并噻唑-5-基)甲胺
英文名称:
(1-methylbenzotriazol-5-yl)methanamine
英文别名:
1-Methyl-1H-benzotriazole-5-methanamine;

(1-methylbenzotriazol-5-yl)methylamine;

CAS号:
499770-77-3
分子式:
C8H10N4
分子量:
162.19200
精确质量:
162.09100
PSA:
56.73000
LogP:
1.12730

物化性质

密度:
1.34g/cm3
熔点:
63-67ºC
沸点:
350.7ºC at 760mmHg
闪点:
165.9ºC
折射率:
1.691

安全信息

  • 危险类别码:R20; R34
  • 安全说明:S26-S36/37/39-S45

MSDS

  • MSDS
Name: (1-Methyl-1H-1 2 3-benzotriazol-5-yl)methylamine 97% Material Safety Data Sheet
Synonym:
CAS: 499770-77-3

Section 1 – Chemical Product   MSDS Name:(1-Methyl-1H-1 2 3-benzotriazol-5-yl)methylamine 97% Material Safety Data Sheet
Synonym:


Section 2 – COMPOSITION, INFORMATION ON INGREDIENTS

CAS# Chemical Name content EINECS#
499770-77-3 (1-Methyl-1H-1,2,3-benzotriazol-5-yl)m 97 unlisted

Hazard Symbols: C
Risk Phrases: 34 20


Section 3 – HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Causes burns. Harmful by inhalation.
Potential Health Effects
Eye:
Causes eye burns.
Skin:
Causes skin burns.
Ingestion:
Causes gastrointestinal tract burns.
Inhalation:
Harmful if inhaled. Causes chemical burns to the respiratory tract.
Chronic:
Not available.


Section 4 – FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Do not induce vomiting. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.


Section 5 – FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide.


Section 6 – ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container.


Section 7 – HANDLING and STORAGE
Handling:
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Corrosives area.


Section 8 – EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 499770-77-3: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.


Section 9 – PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 63 – 67 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C8H10N4
Molecular Weight: 162.2


Section 10 – STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported


Section 11 – TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 499770-77-3 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
(1-Methyl-1H-1,2,3-benzotriazol-5-yl)methylamine – Not listed by ACGIH, IARC, or NTP.


Section 12 – ECOLOGICAL INFORMATION


Section 13 – DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.


Section 14 – TRANSPORT INFORMATION

IATA
Shipping Name: CORROSIVE SOLID, TOXIC, N.O.S.*
Hazard Class: 8 (6.1)
UN Number: 2923
Packing Group: III
IMO
Shipping Name: CORROSIVE SOLID, TOXIC, N.O.S.
Hazard Class: 8 (6.1)
UN Number: 2923
Packing Group: III
RID/ADR
Shipping Name: CORROSIVE SOLID, TOXIC, N.O.S.
Hazard Class: 8
UN Number: 2923
Packing group: III


Section 15 – REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 20 Harmful by inhalation.
R 34 Causes burns.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 499770-77-3: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 499770-77-3 is not listed on Canada’s Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 499770-77-3 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 – ADDITIONAL INFORMATION
N/A

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