化合物简介
Stigmatellin is a potent inhibitor of the quinol oxidation (Qo) site of the cytochrome bc1 complex in mitochondria and the cytochrome b6f complex of thylakoid membranes.
Stigmatellin is isolated from the myxobacterium Stigmatella aurantica, and contains a 5,7-dimethoxy-8-hydroxychromone aromatic headgroup with a hydrophobic alkenyl chain in position 2 . Crystal structures for stigmatellin-inhibited bovine and yeast (Saccharomyces cerevisiae) bc1 complex are available. Stigmatellin binds at the cytochrome b Qo site in the ‘(heme) bl distal’ position, and associates with the Rieske iron-sulfur protein via a hydrogen bond to histidine residue 181 (His-181), a ligand to the [2Fe2S] iron-sulfur cluster of this subunit. This association raises the midpoint potential of the iron-sulfur cluster from 290 to 540 mV and restricts movement of the cytoplasmic domain of the Rieske protein.
Stigmatellin is isolated from the myxobacterium Stigmatella aurantica, and contains a 5,7-dimethoxy-8-hydroxychromone aromatic headgroup with a hydrophobic alkenyl chain in position 2 . Crystal structures for stigmatellin-inhibited bovine and yeast (Saccharomyces cerevisiae) bc1 complex are available. Stigmatellin binds at the cytochrome b Qo site in the ‘(heme) bl distal’ position, and associates with the Rieske iron-sulfur protein via a hydrogen bond to histidine residue 181 (His-181), a ligand to the [2Fe2S] iron-sulfur cluster of this subunit. This association raises the midpoint potential of the iron-sulfur cluster from 290 to 540 mV and restricts movement of the cytoplasmic domain of the Rieske protein.
基本信息
- 中文名称：
- 标桩菌素
- 英文名称：
- STIGMATELLIN
- 英文别名：
- Stigmatellin A
- CAS号：
- 91682-96-1
- 分子式：
- C30H42O7
- 分子量：
- 514.65000
- 精确质量：
- 514.29300
- PSA：
- 87.36000
- LogP：
- 6.13760
物化性质
- 密度：
- 1.081g/cm3
- 熔点：
- 82-89ºC /Technical grade 82-90% purity/
- 沸点：
- 635ºC at 760mmHg
- 闪点：
- 198.1ºC
- 折射率：
- 1.527
- 储存条件：
- -20ºC
安全信息
- 包装等级：II
- 危险类别：6.1(a)
- 危险品运输编码：UN 2811 6.1/PG 2
- 危险类别码：R25
- 危险品标志：T
