产物需要游离态,如果有手性,最好提供相关数据图谱。常温至150度内TGA失重不超过2%。需提供HNMR、MS、HPLC测试图谱和HPLC测试方法。
化合物简介
LGX 818 is potent and selective BRAFV600E kinase inhibitor and can be used for the treatment of proliferative diseases such as solid tumor diseases.
基本信息
中文名称:Encorafenib
英文名称:methyl N-[(2S)-1-[[4-[3-[5-chloro-2-fluoro-3-(methanesulfonamido)phenyl]-1-propan-2-ylpyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate
英文别名:UNII-8L7891MRB6;methyl N-[(2S)-1-({4-[3-(5-chloro-2-fluoro-3-methanesulfonamidophenyl)-1-(propan-2-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl}amino)propan-2-yl]carbamate;LGX-818;Encorafenib;
(S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate;
CAS号:1269440-17-6
分子式:C22H27ClFN7O4S
分子量:540.01100
精确质量:539.15200
PSA:152.00000
LogP:5.33960