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化合物简介
(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine is a used in the synthetic preparation of 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of epidermal growth factor receptor. It is also used in the preparation of (2Z)-Afatinib which is used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
基本信息
- 中文名称：
- N-(3-氯-4-氟苯基)-6-硝基-7-[[(3S)-四氢-3-呋喃基]氧基]-4-喹唑啉胺
- 中文别名：
- 4-[(3-氯-4-氟苯基)氨基]-6-硝基-7-((S)-四氢呋喃-3-基氧基)-喹唑啉
- 英文名称：
- N-(3-chloro-4-fluorophenyl)-6-nitro-7-[(3S)-oxolan-3-yl]oxyquinazolin-4-amine
- 英文别名：
- (S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine;
(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine;
4-[(3-Chloro-4-fluorophenyl)amino]-6-nitro-7-((5)-tetrahydrofuran-3-yloxy)-quinazoline;
(2Z)-Afatinib intermediate;
- CAS号：
- 314771-88-5
- 分子式：
- C18H14ClFN4O4
- 分子量：
- 404.78000
- 精确质量：
- 404.06900
- PSA：
- 102.09000
- LogP：
- 4.83800
